IMES EDITING AND CONSULTING STAFF
The IMES editing staff is composed of highly trained, experienced, and well-published specialists in a range of basic and clinical research activities. These experts can provide comprehensive reviews of authors’ manuscripts, with critical assessment of study design, statistical methods, manuscript organization, stylistic presentation, and literature review.
Basic and clinical specialties represented by our staff include molecular biology, cellular biology, genetics, clinical epidemiology, clinical trial design, biostatistical analysis, computerized testing methods, general internal medicine, general surgery, hepatology, gastroenterology, gastrointestinal endoscopy, infectious diseases, oncology, pharmacology, endocrinology, histopathology, and clinical imaging methods.
William R. Brown, M.D. Professor of Medicine Emeritus, University of Colorado School of Medicine, Denver CO Please see “About Our Director.”
International Medical Editing Service is pleased to announce that Prof. Elod Erno Nagy and colleagues from the University of Medicine, Pharmacy, Sciences and Technology, Tirgu Romania, have had an impressive, comprehensive review of the pathogenesis of osteoarthritis published in International Journal of Molecular Sciences. The paper highlights evolving concepts that deterioration of the cartilage can be preceded by synovitis, low-grade inflammation, and remodeling of the subchondral bone. https://www.mdpi.com/1422-0067/20/18/4653/pdf.
Dennis Ahnen, M.D. Professor of Medicine Emeritus, University of Colorado School of Medicine, Denver CO Dr. Ahnen received his MD degree from Wayne State University, Detroit, and fellowship training in gastroenterology at the University of Colorado School of Medicine. He is an international authority on colorectal cancer prevention and the genetics and familial expression of the disease. Dr. Ahnen has published over 250 articles in the area of colon cancer prevention. He is a co-Investigator on three grants funded by the National Cancer Institute. He serves on the Steering Committee of the VA Cooperative Group Trial #577 (CONFIRM), The Colon Cancer Family Registry and the National Colorectal Cancer Roundtable and on the Council of the Collaborative Group of the Americas. He serves on the Colorectal Cancer Screening and Genetics Guidelines Committee of the National Comprehensive Cancer Network. He is the co-director of the Hereditary Cancer Clinic at the University of Colorado School of Medicine and Director of the Genetics Clinic of Gastroenterology of the Rockies.
- Baron JA, Barry EL, Mott LA, Rees JR, Sandler RS, Snover DC, Bostick RM, Ivanova A, Cole BF, Ahnen DJ, et al. A Trial of Calcium and Vitamin D for the Prevention of Colorectal Adenomas. N Engl J Med. 2015 Oct 15;373(16):1519-30. doi: 10.1056/NEJMoa1500409. PMID: 26465985
- Levine AJ, Phipps AI, Baron JA, Buchanan DD, Ahnen DJ, et al. Clinicopathologic Risk Factor Distributions for MLH1 Promoter Region Methylation in CIMP-Positive Tumors. Cancer Epidemiol Biomarkers Prev. 2016;25:68-75. doi: 10.1158/1055-9965.EPI-15-0935. Epub 2015 Oct 28. PMID: 26512054
- Patel SG, Schoenfeld P, Kim HM, Ward EK, Bansal A, Kim Y, Hosford L, Myers A, Foster S, Craft J, Shopinski S, Wilson RH, Ahnen DJ, Rastogi A, Wani S. Real-Time Characterization of Diminutive Colorectal Polyp Histology Using Narrow-Band Imaging: Implications for the Resect and Discard Strategy. 2016 Feb;150(2):406-18. doi: 10.1053/j.gastro.2015.10.042. Epub 2015 Oct 30. PMID: 26522260
Min Yao, MD, MPH Dr. Yao graduated from Fudan University School of Medicine, in China, and Boston University School of Public Health. He specializes in clinical research methodology, multi-center randomized clinical trials, data management, and statistical analysis. Dr. Yao is in charge of all 3M clinical studies in Greater China (Mainland China, Taiwan, and Hong Kong). Dr. Yao is also developing a consulting business to assist Chinese physicians in the design and execution of clinical research programs.
- Yao M, Fabbi M, Hayashi H, Park N, Attala K, Gu G et al. A retrospective cohort study evaluating efficacy in high-risk patients with chronic lower extremity ulcers treated with negative pressure wound therapy. Int Wound J 2012; Nov 19. doi: 10.1111/iwj.12005. [Epub ahead of print]
- Yao M, Hasturk H, Kantarci A, Gu G, Garcia-Lavin S, Fabbi M et al. A pilot study evaluating noncontact low frequency ultrasound and underlying molecular mechanism on diabetic foot ulcers. Int Wound J 2012;
- Driver VR, Yao M, and Miller CJ. Noncontact low-frequency ultrasound therapy in the treatment of chronic wounds: a meta-analysis. Wound Repair Regen 2011;19: 475-480.
- Driver VR and Yao M. Discussion. Current status of the use of modalities in wound care: electrical stimulation and ultrasound therapy. Plast Reconstr Surg 2011;127 Suppl 1: 103S-104S.
- Yao M, Kargman S, Lam EC, Kelly CR, Zheng Y, Luk P et al. Inhibition of cyclooxygenase-2 by rofecoxib attenuates the growth and metastatic potential of colorectal carcinoma in mice. Cancer Res 2003;63: 586-592.
Dr. Nakane earned his Ph.D. degree from Brown University, Providence RI, and his D. Med. Sci degree from Keio University, in Japan. He has held the positions of Professor of Pathology at the University of Colorado School of Medicine; Professor and Chairman of the Department of Histology and Cell Biology of Nagasaki University School of Medicine; and director of the Tokai University Medical Research Institute. He is renowned for having developed the widely used enzyme-labeled immunohistochemistry antibody method. Among his many awards is receipt of an award in his name, and the David Glick Award, from the International Federation of Societies for Histochemistry and Cytochemistry.
- Nakane PK, Pierce GB Jr. Enzyme-labeled antibodies for the light and electron microscopic localization of tissue antigens. J Cell Biol. 1967; 33:307-318.
- Kawarai Y, Nakane PK. Localization of tissue antigens on the ultrathin sections with peroxidase-labeled antibody method. J Histochem Cytochem. 1970;18:161-166.
- Nagura H, Nakane PK, Brown WR. Translocation of dimeric IgA through neoplastic colon cells in vitro. J Immunol. 1979; 123:2359-2368.
- Nogae S, Miyazaki M, Kobayashi N, Saito T, Abe K, Saito H, Nakane PK, et al. Induction of apoptosis in ischemia-reperfusion model of mouse kidney: possible involvement of Fas. J Am Soc Nephrol. 1998; 9:620-631.
Alvaro Martinez-Camacho, M.D. Assistant Professor of Medicine, University of Colorado School of Medicine and Denver Health Medical Center, Denver CO Dr. Martinez-Camacho received his MD degree from Wayne State University School of Medicine, in Detroit MI. He is a highly trained, experienced, and respected hepatologist. He received advanced training in liver diseases and liver transplantation at the University of Colorado School of Medicine and the Baylor College of Medicine, Houston, Texas. He is an authority on the management of acute and chronic viral hepatitis, metabolic and genetic liver diseases, and liver transplantation.
- Martinez-Camacho A, Khaoustov VI, Adam E, et al. Lymphocytosis as a pedictor of poor response to treatment of hepatitis C. Clin Res Hepatol Gastroenterol. 2011;35: 34-40.
- Goldberg DS, Camp A, Martinez-Camacho A, et al. Risk of waitlist mortality in patients with primary sclerosing cholangitis and bacterial cholangitis. Liver Transpl. 2013; 19: 250-258.
- Martinez-Camacho A. Treating HCV prior to liver transplantation. In: Shiffman M, ed. Chronic Hepatitis C Virus: Advances in Treatment, Promises for the Future. Springer. 2012, pp 301-312
- Fortune B, Martinez-Camacho A, Kreidler S, et al. Post-transplant survival is improved for hepatitis C recipients who are RNA negative at time of liver transplant. Transpl Int 2015 Mar 26.doi:10.1111/tri.12568
Zhihua Ran, M.D. Ph.D. Professor of Medicine, Shanghai Jiao Tong University School of Medicine; Director, Shanghai Inflammatory Bowel Disease Research Center; Associate Director, Department of Gastroenterology, Ren Ji Hospital; Associate Director, Shanghai Institute of Digestive Disease; Executive Editor, Journal of Digestive Diseases
Professor Ran is an internationally recognized authority in research and clinical aspects of chronic inflammatory bowel diseases. He holds a Bachelor’s Degree in Medicine and a Master’s Degree in Gastroenterology from Shanghai Second Medical University, Shanghai, China; and a doctoral degree in medicine from the German Cancer Research Center, Heidelberg University, Germany. He is Chairman of the Educational Committee of the Asian Organization of Crohn’s and Colitis. He was a visiting scholar at Mayo Clinic, Rochester, USA, in 2004. Professor Ran brings to IMES his extensive knowledge in the inflammatory bowel diseases and in the practice of medicine and medical research in Asia. Selective publications from 2015-16
- Wu KC, Ran ZH, Gao X, et al. Adalimumab induction and maintenance therapy achieve clinical remission and response in Chinese patients with Crohn’s disease. Intest Res. 2016 Apr;14(2):152-63.
- Xu AT, Lu JT, Ran ZH, et al. Exosomes in Intestinal Mucosal Immunity. J Gastroenterol Hepatol. 2016 Apr 8. doi: 10.1111/jgh.13413. [Epub ahead of print]
- Ma JY, Tong JL, Ran ZH. Intestinal tuberculosis and Crohn’s disease: Challenging Differential Diagnosis. J Dig Dis. J Dig Dis. 2016 Mar;17(3):155-61
- Xu AT, Tong JL, Ran ZH. Organoids Derived from Digestive tract, liver, and pancreas. J Dig Dis. 2015 Dec 15. doi: 10.1111/1751-2980.12305. [Epub ahead of print]
- Nie F, Cao J, Tong J, Zhu M, Gao Y, Ran Z. Role of Raf-kinase inhibitor protein in colorectal cancer and its regulation by hydroxycamptothecine. J Biomed Sci. 2015 Jul 16;22:56
Jennifer Brown, M.D. Associate Professor of Medicine, Infectious Diseases Division, University of California Davis School of Medicine, Sacramento CA. Dr. Brown received her MD degree from the University of California Davis Medical School. She conducted basic research in the Department of Molecular Biology of the University of Southern California and at the National Centers for Infectious Diseases of the U.S. Center for Disease Control and Prevention. She received clinical fellowship training in medical toxicology and infectious diseases. She is certified in internal medicine and infectious diseases by the American Board of Internal Medicine. Her major clinic emphasis is on the care of patients with AIDS and its related illnesses and of organ-transplant recipients.
- Brown J, Li C-S, Giordani M, Shahlaie K, Klineberg EO, Tripet-Diel JR, Ihara MS, Cohen SH. Swabbing surgical sites does not improve the detection of Staphylococcus aureus carriage in high-risk surgical patients. Surg Infect. 2015;16(5):523-5.
- Brown J. Use of the Cystic Fibrosis Foundation’s extensive sputum culturing protocol for patients without cystic fibrosis: Implications for infection control and antimicrobial resistance. Am J Infect Control. 2014;42(5):546-547.
- Nand P, Wilson MD, Cohen SH, Brown J. Curbing antimicrobial resistance: Do physicians receive adequate education about antibiograms? J Infect. 2016;72(1):127-9.
- Bui C, Zhu E, Donnelley MA, Wilson MD, Morita M, Cohen SH, Brown J.
Antimicrobial stewardship programs that target only high-cost broad-spectrum antimicrobials miss opportunities to reduce Clostridium difficile infections. Am J Infection Control. 2016 Dec 1;44(12):1684-1686.
Angela Keniston, MSPH
Ms. Keniston received her MSPH degree from the Universityof Colorado Health Sciences Center. She is a member of the Colorado Public Health Association, the Denver Health Research Staff Forum, and the Denver Health Biostatics Working Group. She is exceptionally talented and experienced in clinical research design, execution, and outcomes evaluation.
- Rylander M, Colon-Sanchez D, Keniston A, Hamalian G, Lozano A, Nussbaum AM. Risk Factors for Readmission on an Adult Inpatient Psychiatric Unit. Qual Manag Health Care. 2016 Jan-Mar;25(1):22-31.
- Indovina K, Keniston A, Reid M, Sachs K, Zheng C, Tong A, Hernandez D, Bui K, Ali Z, Nguyen T, Guirguis H, Albert RK, Burden M. Real-time patient experience surveys of hospitalized medical patients. J Hosp Med. 2016 Jan 18.
- Pierce C, Keniston A, Stickrath C. Frequency of Attending Physician-Led Discussion of Test-Ordering Principles During Teaching Rounds. JAMA Intern Med.2016 Feb 1;176(2):261-2.
- Cervantes L, Linas S, Keniston A, Fischer S. Latinos With Chronic Kidney Failure Treated by Dialysis: Understanding Their Palliative Care Perspectives. Am J Kidney Dis. 2016 Feb;67(2):344-7.
- Geoff Chambers, PhD. Research and Teaching Fellow, School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand, and Visiting Professor at Universiti Sains Malaysia, Penang Dr. Chambers is an authority in the fields of evolution, genetics and molecular biology. The central theme of his research is the development and application of methods to measure genetic variability in populations. His current work focuses on the use of polymerase chain reaction-catalyzed amplification of target genes, DNA sequencing, and microsatellite DNA genotyping analyses in forensic science, human disease diagnosis, and wildlife conservation. Dr. Chambers’ work can be followed at https://www.researchgate.net/profile/Geoff_Chambers
- Manaf, SM., Nur Waliyuddin H.Z.A., Paneerchelvam, S., Chambers G.K., Zafarina, Z., Norazmi, M. and Edinur, H.A. (2015) Human neutrophil antigen profiles in Banjar, Bugis, Champa, Jawa, and Kelantan Malays in Peninsular Malaysia. Blood Transfusion 13: 610-615.
- Nur Waliyuddin H.Z.A., Norazmi, M.N., Edinur, H.A, Chambers, G.K., Paneerchelvam, S. and Zafarina, Z. (2015) Ancient genetic signatures of Orang Asli revealed by Killer Immunoglobulin-like Receptor gene polymorphisms. PLoS ONE 10: e0141536.
- Syafawati, W.U.W., Norhalifah, H.K., Syaza, F.H. Zafarina, Z., Panneerchelvam, S., Norazmi, M.N., Chambers, G.K. and H.A. Edinur (2015). Gene frequencies of human platelet antigens in Banjar, Bugis, Champa, Jawa and Kelantan Malays in Peninsular Malaysia. Transfus. Med. 25: 326-332.
- Didham, R., Callister P. and Chambers G.K. (2018). Multidimensional intersections: The merging and emerging of complex European settler identities. Pp. 171-192 in Mana Tangatarua: Mixed heritages, ethnic identity and biculturalism in Aotearoa/New Zealand, edited by Rocha, Z.L. and Webber M. eds., Routledge, Abingdon, UK.
- Edinur, H.A., Rasudin, N.S., Ghafar, N.A. and Chambers, G.K. (2018). The Austronesian Diaspora from an HLA perspective. pp. in Adv. Med. Biol 204 Bernhardt L.J. Ed. NOVA Science Publishers Inc., New York.
- Chambers G.K. and Callister P. (2018). Finding out who we really are. Appeared under the title DNA tests all very well but they only take us so far On the Opinion Page A7 of The Dominion Post 03-APR-18 Fairfax Media, Wellington NZ.
Mary D. Schneider, PhD Freelance Medical Editor/Writer Alberta, Canada Dr. Schneider is a PhD graduate of the University of Alberta. She has conducted advanced basic research in unusual metabolic properties of toxic mRNA in myotonic dystrophy; the role of proteases in cellular organelle morphology and inheritance; and an animal model for a disease caused by mutations in the untranslated RNase MRP RNA gene.
- Prevec, L., M. Schneider, K.L. Rosenthal, L.W. Belbeck, J.B. Derbyshire and F.L. Graham. 1989. Use of human adenovirus-based vectors for antigen expression in animals. J Gen Virol. 70 ( Pt 2):429-34.
- Schneider, M., F.L. Graham and L. Prevec. 1989. Expression of the glycoprotein of vesicular stomatitis virus by infectious adenovirus vectors. J Gen Virol. 70 ( Pt 2):417-27.
- Schneider, M.D., N. Najand, S. Chaker, J.M. Pare, J. Haskins, S.C. Hughes, T.C. Hobman, J. Locke, and A.J. Simmonds. 2006. Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development. J Cell Biol. 174:349-58.
- Schneider, M., A.K. Bains, T.K. Rajendra, Z. Dominski, G. Matera and A.J. Simmonds. 2010. Functional characterization of the Drosophila MRP (mitochondrial RNA processing) RNA gene. RNA. November 2010 16: 2120-21
Tracy K. McIntosh, PhDMedia NeuroConsultants, Inc., Chester, Pennsylvania
Dr. McIntosh received his Ph.D. in Neuroscience from Rutgers University. He has held faculty positions at Boston University Medical School; University of California, San Francisco; and the University of Connecticut Health Center. He was the Robert A. Groff Professor of Research and Education in the Department of Neurosurgery at the University of Pennsylvania, where he was Director of Penn’s Head Injury Center for 12 years. His many awards include a Fulbright Fellowship to the University of Lund, Sweden, and the Dorothy Russell Medal for Research in Brain Injury from the Royal Society of Neuropathologists. His research emphasis is in the area of traumatic brain injury, concussion, neurodegenerative diseases, stem cell biology, and neuropharmacology. Dr. McIntosh has published over 300 peer-reviewed articles.
- Tomasevic G, Laurer HL, Mattiasson G, Van Steeg H, Wieloch, T, McIntosh TK. Delayed neuromotor recovery and increased memory acquisition dysfunction following experimental brain trauma in mice lacking the DNA repair gene XPA. J. Neurosurgery 116: 1368-1378, 2012.
- Lazzarino G, Vagnozzi R, Signoretti S, Manara M, Floris R, Amorino AM, Ludovici A, Marziali S, McIntosh TK, Tavazzi, B. The Importance of Restriction from Physical Activity in the Metabolic Recovery of Concussed Brain. In: Brain Injury: Pathogenesis, Monitoring, Recovery and Management. A. Agrawal (Ed.), InTech, (pp. 501-522), 2012.
- Vogel,EW, Morrison B, Evilsizor MN, Griffiths DR, Thomas TC, Lifshitz, J, Sutton, RL,Long, JB, Ritzen, D, Ling, GSF,Huh, J, Raghupathi, R, McIntosh, TK.Experimental Models of Traumatic Brain Injury: Clinical Relevance and Shortcomings. In: “Cell Therapy for Neurological Injury”, C. Cox (ed). CRCPress, pp. 101-166, 2016.
Charles J. Bedord, PhD Freelance Medical Editor/Writer Dr. Bedord received his PhD in biochemistry from the University of Wyoming and conducted postdoctoral research in biochemistry and enzymology at Washington State University. He brings to IMES extensive basic science knowledge as well as valuable education (University of California, Santa Cruz) and experience in writing regulatory documents (clinical development documents such as INDs) for submission to the Food and Drug Administration. He also has extensive experience in editing manuscripts written by non-native English-speaking scientists for publication in peer-reviewed journals. Dr. Bedord’s CV.
Publications and presentations
- Bedord CJ: Project Management in the Small Company Environment. Paper presented at the conference on Accelerating Preclinical Development, 1998
- Bedord CJ, Koplowitz LP, Stead RB: Making the Decision to Continue Your Studies in human subjects. Panel discussion at the conference on Accelerating Preclinical Development, 199816)
- Bedord CJ: Making the Decision to Initiate Studies in Human Subjects. Paper presented at the conference on Accelerating Preclinical Development, 1999
- Bedord CJ: Project Management of Exploratory Drug Development. Paper presented at the conference on Exploratory Drug Development, 2000
Colleen Walacavage, MA, CPhT Editor, CW Editing Service, LLC, Burke VA. Ms. Walacavage received her MA from George Mason University in English, Professional Writing and Editing, and her BA in Policy and Management Studies from Dickinson College. She is the sole proprietor and chief editor of CW Editing Service, which provides professional editing and writing services to businesses and individuals, particularly in the fields of healthcare, medicine, and education. In addition, she works as a Certified Pharmacy Technician at CVS Health. She has worked with Dr. Brown for several years as a copy editor and proofreader, and in reference citation and formatting.
Ms. Andrieux is the business manager of International Medical Editing Service. She can be contacted on whatsapp +852-93975805 or
Prof. Elod Erno Nagy and colleagues from the University of Medicine, Pharmacy, Sciences and Technology, Tirgu Romania, have had an impressive, comprehensive review of the pathogenesis of osteoarthritis published in International Journal of Molecular Sciences. The paper highlights evolving concepts that deterioration of the cartilage can be preceded by synovitis, low-grade inflammation, and remodeling of the subchondral bone.